Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory
- Patrick Allard
- Jan 7, 2019
- 1 min read
How organisms retain a memory of ancestral environmental exposure is a phenomenon that is still poorly understood. Recently published work by our group and others, regarding environmentally induced transgenerational effects, have identified an array of mechanisms, with a particular focus on histone modifications, that shed some light on the underlying epigenetic processes driving long-term generational effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233965/
Histone modifications truly lie at the core of transgenerational inheritance studies. Although this piece is from 2019, it serves as an excellent starting point for reviewing environmentally induced memory mechanisms. I'm keen to see future research detail how specific histone marks precisely regulate these effects across generations. This review's framework is very insightful.
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