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EpiCenter publication: early mammalian germ cells are highly sensitive to environmental exposures
- Patrick Allard
- Oct 6, 2021
- 1 min read
In mammalian embryos, the early germ cells, termed Primordial Germ Cells, undergo a highly specialized differentiation program associated with a profound reprogramming of their epigenome. Here, we tested the sensitivity of mouse primordial germ cells to a model environmental chemical, the plastic manufacturing chemical Bisphenol A (BPA), and show that while primordial germ cells may "look" normal, their molecular program is strongly affected with aberrant X-linked and retrotransposon desilencing.
Read the article here!
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Fascinating findings—especially how hidden environmental impacts can influence long-term outcomes. It’s a good reminder that in real estate too, what’s beneath the surface matters. Whether it's location history, land use, or future development plans, deep research is key. We’ve seen this firsthand while working in emerging smart zones like Dholera Smart City, where sustainable infrastructure and thoughtful planning make a huge difference.
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