EpiCenter publication: early mammalian germ cells are highly sensitive to environmental exposures
- Patrick Allard
- Oct 6, 2021
- 1 min read
In mammalian embryos, the early germ cells, termed Primordial Germ Cells, undergo a highly specialized differentiation program associated with a profound reprogramming of their epigenome. Here, we tested the sensitivity of mouse primordial germ cells to a model environmental chemical, the plastic manufacturing chemical Bisphenol A (BPA), and show that while primordial germ cells may "look" normal, their molecular program is strongly affected with aberrant X-linked and retrotransposon desilencing.
Read the article here!
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This is such an illuminating exploration of primordial germ cell sensitivity—it underscores just how environmental exposures can ripple through critical developmental stages. Your findings really emphasize the value of robust and transparent data handling in sensitive research fields. As someone associated with a blockchain development company, I find the principles of immutability and traceability particularly intriguing in this context—imagine how maintaining a tamper-proof record of experimental data could strengthen reproducibility and trust in future scientific studies. Thank you for bringing attention to such an essential aspect of developmental biology.